Buy A-PiHP Crystal | 4mmcchems – Premium Research Chemical.

Introduction to A-PiHP Crystal.

A-PiHP (alpha-Pyrrolidinoisohexanophenone), also known as α-PiHP or 4-methyl-α-PVP, is a synthetic cathinone belonging to the pyrovalerone class of compounds. It is a positional isomer of A-PHP, distinguished by a methyl group substitution at the 4-position of the pentyl chain. First reported in seized materials in China in 2016, A-PiHP has since become one of the most frequently detected new psychoactive substances across Europe.

As a research chemical, A-PiHP is primarily utilized as a certified reference material for forensic and toxicological applications. Its detection in forensic casework across 18 EU Member States has established it as an important standard for analytical method development. At 4mmcchems, we supply premium-grade A-PiHP Crystal to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.

Product Specifications

Product Name: A-PiHP Crystal (alpha-Pyrrolidinoisohexanophenone)

Synonyms: α-PiHP, 4-methyl-α-PVP, α-Pyrrolidinoisohexanophenone

CAS Number: 2181620-71-1 (free base); 2705245-60-7 (hydrochloride salt)

Molecular Formula: C₁₆H₂₃NO · HCl

Molecular Weight: 245.36 g/mol (free base); 281.82 g/mol (HCl salt)

Purity: ≥ 98% (verified by third-party HPLC/GC-MS testing)

Form: Crystalline solid

Storage: -20°C for long-term stability

Availability: In stock, ready for immediate dispatch

Chemical Properties and Mechanism of Action

A-PiHP acts as a potent inhibitor of the dopamine transporter (DAT) and norepinephrine transporter (NET), with negligible activity at the serotonin transporter (SERT). Unlike some synthetic cathinones that function as substrate releasers, A-PiHP acts as a pure reuptake inhibitor, blocking the reuptake of neurotransmitters without inducing their release.

Key Pharmacological Data

• DAT Inhibition (IC₅₀): 14 nM – demonstrating extremely high potency, with effects comparable to α-PVP

• NET Inhibition (IC₅₀): 13 nM – also highly potent at inhibiting norepinephrine uptake

• SERT Inhibition (IC₅₀): >36,000 nM – negligible activity, resulting in a DAT/SERT ratio of approximately 2,639

• Potency Rank Order: DAT ≈ NET >> SERT, indicating high selectivity for catecholamine systems

This pharmacological profile—potent DAT and NET inhibition with minimal SERT interaction—produces strong psychostimulant effects without empathogenic properties. In vivo studies demonstrate that A-PiHP induces dose-dependent hyperlocomotion, with an ED₅₀ of 4.0 mg/kg for total locomotor activity.

Why Choose 4mmcchems?

1. Uncompromising Quality

We source our A-PiHP Crystal from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and GC-MS testing to guarantee purity and potency, meeting the ≥98% purity threshold required for analytical reference materials.

2. Discreet and Secure Packaging

Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.

3. Worldwide Shipping with European Focus

4mmcchems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:

• European Shipping: A-PiHP has been detected in 18 EU Member States and is controlled in at least seven. We have optimized shipping routes to ensure timely delivery to all EU member states, the UK, Switzerland, and more.

• Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.

• Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.

4. Competitive Pricing and Bulk Discounts

We offer tiered pricing for bulk orders, making 4mmcchems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.

5. Responsive Customer Support

Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.

Safety and Regulatory Information

A-PiHP is a controlled substance in many jurisdictions globally. The World Health Organization has recommended that A-PiHP be added to Schedule II of the Convention on Psychotropic Substances of 1971. The compound has been associated with at least four deaths reported by EU Member States and detected in biological samples from serious adverse events.

Important Considerations for Researchers:

• Controlled Status: A-PiHP is controlled in at least seven EU Member States and may be subject to regulation in other jurisdictions. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

• Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use.

• Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound. A-PiHP is associated with serious adverse effects including agitation, paranoia, hypertension, tachycardia, and seizures.

Shipping Information: Worldwide Delivery

4mmcchems is committed to making our products accessible globally. We ship to all major regions, including:

• Europe: All EU member states, UK, Switzerland, Norway, and more.

• North America: USA, Canada, Mexico.

• Asia: Japan, South Korea, Singapore, China, India, and others.

• Australia & Oceania

• South America

• Middle East & Africa

Shipping Methods:

• Standard Air Mail (7-21 days, tracking available)

• Express Courier (3-7 days, fully tracked, signature required)

Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance, subject to local regulations.

How to Order

1. Browse Our Catalog: Select A-PiHP Crystal and add to cart.

2. Checkout: Fill in your shipping details and choose your preferred payment method.

3. Payment: We accept cryptocurrencies and bank transfers for secure transactions.

4. Confirmation: Receive an order confirmation with tracking details upon dispatch.

Frequently Asked Questions

Q: What is A-PiHP used for in research?

A: A-PiHP is used as an analytical reference material for forensic and toxicological applications, including GC-MS and LC-MS testing methods, transporter binding assays, and neuropharmacological studies.

Q: Is A-PiHP legal to purchase?

A: A-PiHP is controlled in at least seven EU Member States and may be subject to regulation in other jurisdictions. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

Q: How should A-PiHP be stored?

A: Store at -20°C for long-term stability. Protect from light and moisture.

Q: What if my order is seized by customs?

A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries, especially given the strict controls on A-PiHP. Please refer to our shipping policy for more details.